Nuclei accumbens phase synchrony predicts decision-making reversals following negative feedback

Cohen MX, Axmacher N, Lenartz D, Elger CE, Sturm V, Schlaepfer TE.: Nuclei accumbens phase synchrony predicts decision-making reversals following negative feedback. J Neurosci. 2009 Jun 10;29(23):7591-8.
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Deep brain stimulation for psychiatric disorders – state of the art

Schlaepfer TE, Bewernick B: Deep brain stimulation for psychiatric disorders-state of the art. Advances and Technical Standards in Neurosurgery 34:37-57, 2009
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Baseline severity of depression predicts antidepressant drug response relative to escitalopram

Kilts CD, Wade A, Andersen H, Schlaepfer TE (2009). Baseline severity of depression predicts antidepressant drug response. Expert Opinion On Pharmacotherapy 10(6): 927-936.
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Noradrenergic enhancement of amygdala responses to fear

Onur O, Walter H, Schlaepfer T, Rehme A, Schmidt C, Keysers C, et al (2009). Noradrenergic enhancement of amygdala responses to fear. Social Cognitive and Affective Neuroscience (SCAN) 4: 119-126.
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Neuroelectric signatures of reward learning and decision-making in the human nucleus accumbens

Cohen M, Axmacher N, Lenartz D, Elger C, Sturm V, Schlaepfer T (2008). Neuroelectric signatures of reward learning and decision-making in the human nucleus accumbens. Neuropschopharmacology 34(7): 1649-1658.
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Stimulating personality: ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purpose

Synofzyk M, Schlaepfer TE. Stimulating personality: Ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes. Journal of Biotechnology. 2008;3(12):1511-1520.
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Magnetic seizure therapy of treatment-resistant depression in a patient with bipolar disorder

Kayser S, Bewernick B, Axmacher N, Schlaepfer T (2009). Magnetic Seizure Therapy of Treatment-Resistant Depression in a Patient with Bipolar Disorder. Journal of ECT 25(2): 137-140.
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Modelling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions

Kukolja J, Schlaepfer T, Keysers C, Klingmüller D, Maier W, Fink G, et al (2008). Modelling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions. The Journal of Neuroscience 28(48): 12868-12876.

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Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage

Hurlemann R, Schlaepfer TE, Matusch A, Reich H, Shah NJ, Zilles K, et al (2009). Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage. Social Cognitive and Affective Neuroscience (SCAN) 4(1): 12868-12876.
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Clinical milestones predict symptom remission over 6-month and choice of treatment of patients with major depressive disorder (MDD)

Wade A, Schlaepfer T, Andersen H, Kilts C (2009). Clinical milestones and choice of treatment predict symptom remission over 6-months of patients with major depressive disorder (MDD). Journal of Psychiatric Research 43 (5): 568-575.
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Good vibrations: Cross-frequency coupling and phase coding in the human nucleus accumbens during reward processing

Cohen M, Axmacher N, Lenartz D, Elger C, Sturm V, Schlaepfer T (2008). Good vibrations: Cross-frequency coupling and phase coding in the human nucleus accumbens during reward processing Cognitive Neuroscience Society Annual Meeting Program 2007 21(5): 875-889.
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Cerebral Blood Flow Effects of Acute Intravenous Heroin Administration

Kosel M, Noss RS, Hämmig R, Wielepp JP, Bundeli P, Heidbreder R, Kinser JA, Brenneisen R, Fisch HU, Kayser S, Schlaepfer TE (2008): Cerebral Blood Flow Effects of Acute Intravenous Heroin Administration. European Journal of Neuropharmacology 18:278-85.

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Vagus Nerve Stimulation for Depression: Efficacy and Safety in A European Study

Schlaepfer T, Frick C, Zobel A, Maier W, Heuse I, Bajbouj M, O'Keane V, Corcoran C, Adolfsson R, Trimible M, Rau H, Hoff H, Padberg F, Müller-Siecheneder F, Audenaert K, Van den Abbeele D, Matthews K, Christmas D, Stanga Z, Hasdemir M (2007): Vagus Nerve Stimulation for Depression: Efficacy and Safety in A European Study Psychological Medicine. 2008;38(5):651-662
PMID: 18177525
DOI: 10.1017/S0033291707001924
Editorial to this paper by D. M. McLoughlin
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Pattern of regional cerebral blood-flow changes induced by acute heroin administration - a perfusion MRI study

Guyer S, Kosel M, Altrichter S, El-Koussy M, Haemmig R, Fisch HU, Lovblad KO, Schlaepfer TE (2007): Pattern of regional cerebral blood-flow changes induced by acute heroin administration - a perfusion MRI study. J Neuroradiol 34:322-329.
PMID: 18022231
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Hirnstimulationsverfahren bei Therapieresistenz [Brain stimulation methods for resistance to therapy]. Nervenarzt 78: 575-581. [Brain stimulation methods for resistance to therapy]

Schläpfer T (2007). Hirnstimulationsverfahren bei Therapieresistenz [Brain stimulation methods for resistance to therapy]. Nervenarzt 78: 575-581.
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Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

Schlaepfer TE, Cohen MX, Frick C, et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropschopharmacology. 2008;33(2):368-377.
PMID: 17429407
DOI:10.1038/sj.npp.13014082007
This paper has been recommended evaluated as a 'Must Read' in the Faculty 1000 Medicine. Read the evaluation here: f1000evaluation
and also recommended in the Faculty 1000 Biology. Read the evaluation here: f1000evaluation
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Deep Brain Stimulation for Parkinson's Disease

Lieb K, Schlaepfer TE (2006). Deep Brain Stimulation for Parkinson's Disease (Letter). N Engl J Med 355(21): 2256.
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Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression

Kosel M, Sturm V, Frick C, Lenartz D, Zeidler D, Brodesser D, et al (2007). Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression. Journal of Psychiatric Research 41(9): 801-803.
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Deep Brain Stimulation for Treatment Refractory Depression

Schlaepfer TE, Lieb K (2005). Deep Brain Stimulation for Treatment Refractory Depression. Lancet 366(9495): 1420-1422.
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Incident mania during therapy with vagus nerve stimulation

Frick C, Kosel M, Schlaepfer TE, Stanga Z, Hasdemir MG (2005). Incident mania during therapy with vagus nerve stimulation. The Journal of ECT 21(3): 197.
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Repetitive transcranial magnetic stimulation of the prefrontal cortex affects divided attention immediately after cessation of stimulation

Wagner M, Rihs TA, Mosimann UP, Fisch HU, Schlaepfer TE (2005). Repetitive transcranial magnetic stimulation of the prefrontal cortex affects divided attention immediately after cessation of stimulation. Journal of Psychiatric Research 40(4): 315-321.
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Decreased frontal white-matter volume in chronic substance abuse

Schlaepfer TE, Lancaster E, Heidbreder R, Strain E, Kosel M, Fisch HU, et al (2006). Decreased frontal white-matter volume in chronic substance abuse. International Journal of Neuropsychopharmacology 9(2): 147-153.
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Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression

Schulze-Rauschenbach S, Harms U, Schlaepfer T, Maier W, Falkai P, Wagner M: Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression. British Journal of Psychiatry 186:410-416, 2005
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Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride

Wagner M, Quednow BB, Westheide J, Schlaepfer TE, Maier W, Kuhn KU: Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride. Neuropsychopharmacology 30(2):381-90, 2005
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Novel physical treatments for major depression: vagus nerve stimulation, transcranial magnetic stimulation and magnetic seizure therapy

Schlaepfer TE, Kosel M: Novel physical treatments for major depression: vagus nerve stimulation, transcranial magnetic stimulation and magnetic seizure therapy. Current Opinion in Psychiatry 17:15-20, 2004
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Learning from the history of Neuroscience - Dogma and patient interests

Schlaepfer TE: Learning from the history of Neuroscience - Dogma and patient interests. The Journal of ECT 20(2):137-8, 2004
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Antidepressant effects of repetitive transcranial stimulation

Holtzheimer P, Avery D, Schlaepfer TE: Antidepressant effects of repetitive transcranial stimulation. British Journal of Psychiatry:541-542, 2004
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Diminished GABAA Receptor Binding Capacity and a DNA Base Substitution in a Patient With Treatment Resistant Depression and Anxiety

Kosel M, Rudolph U, Wielepp JP, Luginbuehl M, Schmitt W, Fisch HU, Schlaepfer TE: Diminished GABAA Receptor Binding Capacity and a DNA Base Substitution in a Patient With Treatment Resistant Depression and Anxiety. Neuropsychopharmacology 29(2):347-350, 2004
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Repetitive Transcranial Magnetic Stimulation (rTMS) as a Putative Treatment for Major Depression – A Sham Controlled Study in Relatively Older Patients

Mosimann UP, Schmitt W, Kosel M, Berkhoff M, Müri RM, Hess CW, Fisch HU, Schlaepfer TE: Repetitive Transcranial Magnetic Stimulation (rTMS) as a Putative Treatment for Major Depression – A Sham Controlled Study in Relatively Older Patients. Psychiatry Research 126(2):123-33, 2004
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Magnetic Seizure Therapy Improves Mood in Refractory Major Depression

Kosel M, Frick C, Lisanby SH, Fisch HU, Schlaepfer TE: Magnetic Seizure Therapy Improves Mood in Refractory Major Depression. Neuropsychopharmacology 28(11):1889-1902, 2003
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Managing the Risks of Repetitive Transcranial Stimulation

Belmaker B, Fitzgerald P, George MS, Lisanby HS, Pascual-Leone A, Schlaepfer TE, Wassermann E: Managing the Risks of Repetitive Transcranial Stimulation. CNS Spectrums 8(7):489, 2003
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Beyond the treatment of epilepsy: New applications of Vagus Nerve Stimulation (VNS) in psychiatry

Kosel M, Schlaepfer TE: Beyond the treatment of epilepsy: New applications of Vagus Nerve Stimulation (VNS) in psychiatry, in Brain Stimulation Methods in the Treatment of Affective Disorders. Edited by Schlaepfer TE. New York, CNS Spectrums, 2003
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Repetitive transcranial magnetic stimulation for the treatment of depression. Systematic review and meta-analysis

Martin JL, Barbanoj MJ, Schlaepfer TE, Thompson E, Perez V, Kulisevsky J: Repetitive transcranial magnetic stimulation for the treatment of depression. Systematic review and meta-analysis. British Journal of Psychiatry 182(6):480-491, 2003
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Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

Schlaepfer TE, Kosel M, Nemeroff CB: Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders. Neuropsychopharmacology 28(2):201-205, 2003
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Safety and feasibility of magnetic seizure therapy (MST) in major depression: Randomized within-subject comparison with electroconvulsive therapy

Lisanby HS, Luber B, Schlaepfer TE, Sackeim HA: Safety and feasibility of magnetic seizure therapy (MST) in major depression: Randomized within-subject comparison with electroconvulsive therapy. Neuropsychopharmacology 28(7):1852-1865, 2003
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Transcranial magnetic stimulation

George MS, Nahas Z, Lisanby SH, Schlaepfer T, Kozel FA, Greenberg BD: Transcranial magnetic stimulation. Neurosurgery Clinics of North America 14(2):283-301, 2003
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Mechanisms and State of the Art of Vagus Nerve Stimulation

Kosel M, Schlaepfer TE: Mechanisms and State of the Art of Vagus Nerve Stimulation. The Journal of ECT 18(4):189-192, 2002
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Transcranial magnetic stimulation for treating depression

Martin JL, Barbanoj MJ, Schlaepfer TE, Clos S, Perez V, Kulisevsky J, Gironell A: Transcranial magnetic stimulation for treating depression. The Cochrane Database of Systematic Reviews 2001(4):Art. No.: CD003493. DOI: 10.1002/14651858.CD003493., 2002
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Hemispheric asymmetry in visuospatial attention assessed with transcranial magnetic stimulation

Müri RM, Bühler R, Heinemann D, Mosimann U, Felblinger J, Schlaepfer TE, Hess CW: Hemispheric asymmetry in visuospatial attention assessed with transcranial magnetic stimulation. Experimental Brain Research 143(4):426-30, 2002
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Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly – Correlation between effect size and coil-cortex distance

Mosimann U, Marré SC, Werlen S, Schmitt W, Hess CW, Fisch HU, Schlaepfer TE: Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly – Correlation between effect size and coil-cortex distance. Archives of General Psychiatry 59(2):560-561, 2002
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Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders

Hoehn-Saric R, Schlaepfer TE, Greenberg BD, McLeod DR, Pearlson GD, Wong SH: Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Research-Neuroimaging 108:89-100, 2001
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Double pulse transcranial magnetic stimulation over the frontal eye field facilitates saccade triggering

Wipfli M, Felblinger J, Mosimann U, Hess CW, Schlaepfer TE, Müri RM: Double pulse transcranial magnetic stimulation over the frontal eye field facilitates saccade triggering. European Journal of Neuroscience 14(3):571-575, 2001
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High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral cortex: EEG topography during waking and subsequent sleep

Graf T, Engeler J, Achermann P, Mosimann U, Noss R, Fisch H-U, Schlaepfer TE: High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral cortex: EEG topography during waking and subsequent sleep. Psychiatry Research-Neuroimaging 107(1):1-9, 2001
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Magnetic Seizure Therapy of Major Depression

Lisanby SH, Schlaepfer TE, Fisch HU, Sackeim HA: Magnetic Seizure Therapy of Major Depression. Archives of General Psychiatry 58(3):303-305, 2001
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Mood effects of repetitive transcranial stimulation (rTMS) of left prefrontal cortex in healthy volunteers

Mosimann UP, Rihs TA, Engeler J, Fisch HU, Schlaepfer TE: Mood effects of repetitive transcranial stimulation (rTMS) of left prefrontal cortex in healthy volunteers. Psychiatry Research 94(3):251-256, 2000
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Repetitive transcranial magnetic stimulation activates specific regions in rat brain

Ji RR, Schlaepfer TE, Aizenman CD, Epstein CM, Qiu D, Huang JC, Rupp F: Repetitive transcranial magnetic stimulation activates specific regions in rat brain. Proceedings of the National Academy of Sciences of the United States of America 95:15635-15640, 1998
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Onset and recovery from panic disorder in the Baltimore Epidemiologic Catchment Area follow-up

Eaton WW, Anthony JC, Romanoski A, Tien A, Gallo J, Cai G, Neufeld K, Schlaepfer TE, Laugharne J, Chen LS: Onset and recovery from panic disorder in the Baltimore Epidemiologic Catchment Area follow-up. British Journal of Psychiatry 173(12):501-507, 1998
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SPECT brain blood flow changes with continuous ligand infusion during previously-learned WCST performance

Tien AY, Schlaepfer TE, Orr W, Pearlson GD: SPECT brain blood flow changes with continuous ligand infusion during previously-learned WCST performance. Psychiatry Research-Neuroimaging 82(1):47-52, 1998
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Self-reported somatization symptoms associated with risk for extreme alcohol use

Tien A, Schlaepfer T, Fisch H: Self-reported somatization symptoms associated with risk for extreme alcohol use. Archives of Family Medicine 7:33-37, 1998
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The site of opioid action in the human brain: mu and kappa agonists produce different subjective and cerebral blood flow effects

Schlaepfer TE, Strain EC, Greenberg BD, Preston KL, Lancaster E, Bigelow GE, Barta PE, Pearlson GD: The site of opioid action in the human brain: mu and kappa agonists produce different subjective and cerebral blood flow effects. American Journal of Psychiatry 155:470-473, 1998
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PET Study of competition between intravenous cocaine and 11C raclopride at dopamine receptors in human subjects

Schlaepfer TE, Pearlson GD, Wong DF, Marenco S, Dannals RF: PET Study of competition between intravenous cocaine and 11C raclopride at dopamine receptors in human subjects. American Journal of Psychiatry 154(9):1209-1213, 1997
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PDF of Editorial on this paper

Mood effects of prefrontal repetitive high frequency transcranial magnetic stimulation (rTMS) in healthy volunteers

Dearing J, George MS, Greenberg BD, Wassermann EM, Schlaepfer TE, Murphy DL, Hallet M, Post RM: Mood effects of prefrontal repetitive high frequency transcranial magnetic stimulation (rTMS) in healthy volunteers. CNS Spectrums 2(1):53-68, 1997
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Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: A preliminary study

Greenberg BD, George MS, Martin JD, Benjamin J, Schlaepfer TE, Altemus M, Wassermann EM, Post RM, Murphy DL: Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: A preliminary study. American Journal of Psychiatry 154:867-869, 1997
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Neuroimaging in affective disorders — Accomplishments and shortfalls

Schlaepfer T, Pearlson G: Neuroimaging in affective disorders — Accomplishments and shortfalls. Child and Adolescent Psychiatric Clinics of North America 6(2):413-430, 1997
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Computerized Wisconsin Card Sorting Test: Comparison with manual administration

Tien AY, Spevack TV, Jones DW, Pearlson GD, Schlaepfer TE, Strauss ME: Computerized Wisconsin Card Sorting Test: Comparison with manual administration. Kaohsiung Journal of Medical Sciences 12(8):479-485, 1996
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Structural differences in the cerebral cortex of healthy female and male subjects: A magnetic resonance imaging study

Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Pearlson GD: Structural differences in the cerebral cortex of healthy female and male subjects: A magnetic resonance imaging study. Psychiatry Research-Neuroimaging 61:129-135, 1995
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Decreased regional cortical gray matter volume in schizophrenia

Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD: Decreased regional cortical gray matter volume in schizophrenia. American Journal of Psychiatry 151(6):842-848, 1994
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Paradoxical effects of mild hypoxia and moderate altitude on human visual perception

Schlaepfer TE, Bartsch P, Fisch HU: Paradoxical effects of mild hypoxia and moderate altitude on human visual perception. Clinical Science 83(5):633-6, 1992
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HIV - Infektion des zentralen Nervensystems

Schläpfer TE, Fisch HU: HIV - Infektion des zentralen Nervensystems: Psychiatrische Konsequenzen. Swiss Medical Weekly 118:571-567, 1988
PDF A1