Selected Recent Publications

Swain C.J, Teran A, Maroto M, Cabello A. (2006) Bioorganic & Medicinal Chemistry Letters 16 6058–606, Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT(2A) ligands.

Swain C. J.,iBabel, CDK News, (2006), vol. 3, issue 1, pages 19-20.

Raubo, P, Kulagowski, J J, Swain, C J, (2003) A stereoselective synthesis of (±)-3-aryl-6-phenyl-1-oxa-7-azaspiro[4.5]-decanes. Synlett (13), 2021-2024.

Harrison T, Owens A P Williams B J, Swain C J, Williams A, Carlson E J, Rycroft W, Tattersall F D, Cascieri M A, Chicchi G G, Sadowski S; Rupniak N M, Hargreaves R J. (2001) An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. Journal of Medicinal Chemistry, 44(24), 4296-9

Swain C J, Rupniak N M J. (1999) Recent developments in Neurokinin Antagonists Annual Reports in Medicinal Chemistry

Harper S, Bilsand J, Young L, Bristow L, Boyce S, Mason G, Rigby M, Hewson L, Smith D, O'Donnell R, O'conner D, Hill R G, Evans D, Swain C, Williams B, Hefti F. (1998) Analysis of the neurotrophic effects of GPI-1046 on neuronal survival and regeneration in culture and in vivo, Neuroscience 88, 1, 257

Ladduwahetty T, Swain C J, Keown L, Seward E M, Haworth K, Owen S, Chambers M, Baker R, Cascieri M A, Hargreaves R J, Iversen L L, MacIntyre D E, Metzger J M, Sadowski S, Shepheard S, Strader C D, Tattersal F D, (1996) L-741,671: A potent orally active human NK1 antagonist, J. Med. Chem. 39, 2907

Cascieri M A, Shiao L, Mills S G, MacCoss M, Swain C J, Yu H, Ber E, Sadowski S, Wu M T, Strader C D, Fong T M. (1995) Characterisation of the Interaction of Diacylpiperazine Antagonists with the human NK1 receptor: Identification of a Common Binding site for structurally Dissimilar Antagonists. Mol. Pharm. 47, 660

MacLeod A M, Merchant K J, Brookfield F, Kelleher F, Stevenson G, Owens A P, Swain C J, Cascieri M A, Sadowski S, Ber E, Strader C D, Macintyre D E, Metzger J M, Ball R G, Baker R. (1994) Identification of L-Tryptophan Derivatives with Potent and Selective Activity at the NK1 receptor. J. Med. Chem. 37, 1269

Cascieri M A, Fong T M, Yu H, Bansai A, Swain C J, Strader C D. (1993). Amino-aromatic interaction between histidine 197 of the NK1 receptor and CP 96345. Nature, 362, 350.

Jenkins P, Symons M C R, Booth S E, Swain C J. (1992) Why is a vinyl anion configurationally stable but a vinyl radical configurationally unstable. Tet. Lett., 33, 3543.

Swain C J, Baker R, Kneen C, Herbert R, Moseley J, Saunders J, Seward E M, Stevenson G I, Beer M, Stanton J, Watling K, Ball R G. (1992) Novel 5-HT3 Antagonists: Indol-3-ylspiro(azabicycloalkane-3,5(4H)-oxazoles). J Med. Chem., 35, 1019.

Swain C J, Baker R, Kneen C, Moseley J, Saunders J, Seward E M, Stevenson G, Beer M, Stanton J, Watling K. (1991) Novel 5 HT3 Antagonists. Indole Oxadiazoles. J. Med. Chem. 34, 140.

Baker R, Boyes A L, Swain C J. (1990) Synthesis of Talaromycins A, B, C and E. J. Chem. Soc. Perkin Trans 1., 1415.

Baker R, O'Mahony M J, Swain C J. (1987) The total synthesis of (+) Milbemycin B3. J. Chem. Soc. Perkin Trans. 1, 1623.

Baker R, Cotterell I F, Ravenscroft P D, Swain C J. (1985) The total synthesis of Ancistrofuran. J. Chem. Soc. Perk I, 2463

Baker R, O'Mahony M J, Swain C J. (1984) The total synthesis of Wintermoth Pheromone. J. Chem. Res. 190

A full list of all 140 publications.