Updated section on Transporters
27/10/09 14:21 Filed in: Medicinal
Chemistry | Brain
Pentration
I’ve added
a page on ABCB1 also known as P-gp and MDR1.
Selecia and Fragment-based drug discovery
I’ve been
working with Selcia to develop
their Fragment-based drug
discovery efforts.
“Fragment screening has recently evolved to become a widely accepted approach to lead discovery. Selcia has established a proprietary approach to detect the weak binding interactions between fragments and therapeutic targets, based on capillary electrophoresis (CE Screen). CE has been used ... as a sensitive and robust screening technology. Selcia has acquired the associated IP and has in addition developed new and proprietary methods tailored for screening fragments.”
This technology offers a number of advantages over other fragment-based screening methodologies.
“Fragment screening has recently evolved to become a widely accepted approach to lead discovery. Selcia has established a proprietary approach to detect the weak binding interactions between fragments and therapeutic targets, based on capillary electrophoresis (CE Screen). CE has been used ... as a sensitive and robust screening technology. Selcia has acquired the associated IP and has in addition developed new and proprietary methods tailored for screening fragments.”
This technology offers a number of advantages over other fragment-based screening methodologies.
Drug Discovery Resources Update
I’ve updated the drug
discovery resources Read
More...
Chemical Sciences and Health Consultation
21/05/09 15:25
The Royal
Society of Chemistry (RSC) is holding a consultation on
the integration of the chemical sciences and medical
research. This consultation focuses on areas such as
education and training, funding mechanisms and problems
of multidisciplinary and translational
research. Read
More...
15th RSC-SCI Medicinal Chemistry Symposium
26/02/09 13:07 Filed in: Medicinal
Chemistry
15th RSC- SCI
Medicinal Chemistry Symposium
6-9 September 2009
Churchill College, Cambridge, UK
FINAL CIRCULAR and APPLICATION FORM Read More...
Medicinal Chemistry Symposium
6-9 September 2009
Churchill College, Cambridge, UK
FINAL CIRCULAR and APPLICATION FORM Read More...
RSC MedChem School
30/01/09 13:28
Royal Society of
Chemistry
Residential School: Medicinal Chemistry
29 June - 3 July 2009, University of Nottingham
Application FORM available here
Course Content:
The course will include the following topics:
All applications should be lodged at the RSC by 2 March 2009
Residential School: Medicinal Chemistry
29 June - 3 July 2009, University of Nottingham
Application FORM available here
Course Content:
The course will include the following topics:
- Computational Chemistry
- Biological Mechanisms
- Pharmacokinetics and Drug Metabolism
- Screening of New Compounds
- Patents
- Molecular Biology in Medicinal Chemistry
- Exploiting a Chemical Lead
- Combinatorial Chemistry and Molecular Diversity
- Case Histories of Drug Discovery
- Toxicology in Drug Discovery
- Pharmaceutical Considerations in Drug Development
- Structure-guided Drug Design
- Physical Properties and Quantitative Structure-Activity Relationships
- Hints and Tips in Medicinal Chemistry
All applications should be lodged at the RSC by 2 March 2009
ADME Book
27/10/08 17:39 Filed in: ADME
Just come
across another book that looks excellent,
Drug-like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization.
Drug-like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization.
15th RSC-SCI Medicinal Chemistry Symposium
26/08/08 13:42 Filed in: Medicinal
Chemistry
Details of 15th RSC-SCI
Medicinal Chemistry Symposium, 6-9 September 2009,
Churchill College, Cambridge, UK. Read
More...