Website Update

30/11/09 14:57

I’ve made some improvements to the navigation in the Drug Discovery Resources and added more content.
In particular I’ve added a section on designing a screening collection, an overview of the phases of drug discovery and updated the section on CYP450 interactions. I’ve also updated the list of key publications and added a book list.

Tags: medicinal chemistry, metabolism

Updated section on Transporters

27/10/09 14:21

I’ve added a page on ABCB1 also known as P-gp and MDR1.

Tags: medicinal chemistry, adme, brian penetration

Selecia and Fragment-based drug discovery

30/09/09 08:38

I’ve been working with Selcia to develop their Fragment-based drug discovery efforts.

“Fragment screening has recently evolved to become a widely accepted approach to lead discovery. Selcia has established a proprietary approach to detect the weak binding interactions between fragments and therapeutic targets, based on capillary electrophoresis (CE Screen). CE has been used ... as a sensitive and robust screening technology. Selcia has acquired the associated IP and has in addition developed new and proprietary methods tailored for screening fragments.”

This technology offers a number of advantages over other fragment-based screening methodologies.