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Bioisosteric Replacements
Aromatic Bioisosteres
Simple replacements
1. Phenyl Pyridyl Thiophene 4-Fluorophenyl
A recent publication by Wermuth (DOI: 10.1039/c1md00074h) describes the influence that introduction of a pyridazine can have on the properties of a molecule. When used as a bioisosteric replacement for a phenyl ring the resulting LogP is reduced by two log units, in other examples they improve water solubility of crystallinity of salts.
Last Update 27 July 2011
Simple Bioisosteres
Carbonyl Bioisosteres
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