To Tell The Truth: There may be no honor among thieves, but can't we find it even in a few good men and women?
Should The Human Brain Retire?: We know that we cannot win forever. We know that machines will continue to improve. So why don't we let the human brain retire gracefully now, with honors?
Terrorism Blinded Me With Science: Researchers Creating Ultra-Deadly
Viruses
Just in time for Halloween, research
that may be far scarier than a ghoul.
If
you could develop a virus so deadly that it always killed research animals and
couldn't be fought using known vaccines, would you do it if your research might
help you explore possible effects of
bioterrorism?
Someone
has.
New Scientist reports
that a scientist funded by the U.S. government has deliberately created an
extremely deadly form of mousepox, a relative of smallpox, through genetic
engineering:
Buller has engineered a mousepox strain that kills 100 per cent of vaccinated mice, even when they were also treated with the antiviral drug cidofovir. A monoclonal antibody that mops up IL-4 did save some, however ...
Buller has also constructed a cowpox virus containing the mouse IL-4 gene, which is about to be tested on mice at the US Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland.
Cowpox infects people, but Buller says the IL-4 protein is species-specific and would not affect the human immune system. The experiments are being done at the second-highest level of biological containment.
The modified mousepox virus appears to be non-infectious—although researchers don't know why. While exploring this puzzle, they also plan to create even more lethal viruses, in biological containment, to study how particularly virulent agents could affect the body.
Is research of this kind necessary or advisable?
Proponents say that terrorists are developing bioweapons and that continued research offers our only hope to prepare to fight pandemics. They may be right—but I'm not convinced. Fear of terrorism justifies almost every government program these days. Yet we haven't yet blown up the Bay Bridge, breached Hoover Dam, or sown American croplands with Agent Orange to explore how terrorists might attack these targets.
We don't know what kind of bioweapon terrorists are developing or where the terrorists who develop them will live. It is always possible, though unlikely, that homegrown super-viruses could escape the lab, could be taken from the lab by terrorists or lab workers paid by terrorists, could be developed by terrorists with the aid of disgruntled lab employees, or could be created using published lab research. To create deadly knowledge is to risk its abuse.
Several regular readers of this blog are bioscientists so I'm curious where you stand on the issue. Am I off base?
Update: For another perspective on this issue, read Future Pundit.