Cutting Edge Topics in Psychiatry and Related Fields
A study group of the psychiatry residents at UCLA-NPI

Organizers: Marissa Caudill, MD PhD, Michael Davis, MD PhD

The Cutting Edge Journal Club is a forum for psychiatry residents to read about topics that may be controversial or timely, to discuss new developments in psychiatry, complementary and alternative therapies, philosophical issues, and other topics from "the bleeding edge of psychiatry", in the felicitous phrasing of Rogues & Renegades in Psychiatry, our predecessor study group.

The reading group will be meeting approximately every 3nd Friday of the month during regular resident lunches.

See also our companion journal club, Classic Readings in psychiatry. 

Practical matters:

The reading group normally meets every third Friday of the month during regular resident lunches. Readings are normally distributed beforehand, along with an email briefly outlining the main concepts and their theoretical and historical context.

Please note: future readings are subject to change. This syllabus is a work in progress and evolves in response to the interests of the residents.

Readings for Academic Year 2008-2009

8/15/2008: Autism, Mercury, and Childhood Vaccines: history and evidence

Discussion leader: Marissa Caudill, MD PhD
Faculty discussant: Ed Ornitz, MD

• Baker, Jeffrey P. (2008) "Mercury, vaccines, and autism: one controversy, three histories." Am J Public Health 98: 244-53.
• Fombonne, Eric (2008) "Thimerosal disappears but autism remains." Arch Gen Psychiatry 65:15-6.
• Schechter, Robert and Judith K. Grether. (2008) "Continuing increases in autism reported to California's developmental services system: mercury in retrograde." Arch Gen Psychiatry 65:19-24.

9/19/2008: Morgellons disease: delusional parasitosis or new infectious disease?

Discussion leader: Edward Spencer, MD
Faculty discussant: TBA

• Savely V, Leitao M, Stricker R. (2006) “The Mystery of Morgellons Disease: Infection or Delusion?” Am J Clin Dermatol, 7 (1):1-5.
• Koblenzer C. (2006) “The Challenge of Morgellons Disease.” J Am Acad Dermatol, 55 (5): 920-922.
• Waddell A, Burke W. (2006) “Morgellons Disease?” J Am Acad Dermatol, 55 (5): 914-915.
• Harvey W. (2007) “Morgellons Disease.” J Am Acad Dermatol, 56 (4): 705-706.
• Marris E. (2006) “Mysterious ‘Morgellons Disease’ prompts US investigation.” Nature Medicine, 12 (9): 982.
  
  Also, take a look at the Morgellons Research Foundation website, http://www.morgellons.org for a sense of what patients are reading about the condition.
  
  Further, optional reading is a review of treatment of DP from the British Journal of Psychiatry:
• Lepping P, Russell I, Freudenmann R. (2007) “Antipsychotic treatment of primary delusional parasitosis.” Br J Psychiatry, 191: 198-205.

10/17/2008: Experimental memory erasure in mice

Discussion leader: Marissa Caudill, MD PhD

• Xiaohua Cao, Huimin Wang, Bing Mei1, Shuming An, Liang Yin, L. Phillip Wang, and Joe Z. Tsien. (2008) “Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation.” Neuron, 60(2): 353-366. http://www.cell.com/neuron/abstract/S0896-6273(08)00768-X

11/21/2008: TBA

Faculty discussant: TBA

• readings TBA

12/19/2008: TBA

Faculty discussant: TBA

• readings TBA

1/16/2009: A New Ethics of Psychiatry: Neuroethics, neuroscience and technology

Discussion leader: Erick Cheung, MD

• Cheung, Erick (2009) “A New Ethics of Psychiatry: Neuroethics, neuroscience and technology.” Journal of Psychiatric Practice, 15:391-401

2/20/2009: Bipolar Disorder and STEP-BD

Discussion leaders: Graham Scanlon, MD, and Carl Fleisher, MD

• Gary S. Sachs, M.D., Andrew A. Nierenberg, M.D., Joseph R. Calabrese, M.D., Lauren B. Marangell, M.D., Stephen R. Wisniewski, Ph.D., Laszlo Gyulai, M.D., Edward S. Friedman, M.D., Charles L. Bowden, M.D., Mark D. Fossey, M.D., Michael J. Ostacher, M.D., M.P.H., Terence A. Ketter, M.D., Jayendra Patel, M.D., Peter Hauser, M.D., Daniel Rapport, M.D., James M. Martinez, M.D., Michael H. Allen, M.D., David J. Miklowitz, Ph.D., Michael W. Otto, Ph.D., Ellen B. Dennehy, Ph.D., and Michael E. Thase, M.D. (2007) “Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression.” N Engl J Med 356(17): 1711-1722.
  
• Joseph F. Goldberg, M.D. Roy H. Perlis, M.D., M.Sc. Charles L. Bowden, M.D. Michael E. Thase, M.D. David J. Miklowitz, Ph.D. Lauren B. Marangell, M.D. Joseph R. Calabrese, M.D. Andrew A. Nierenberg, M.D. Gary S. Sachs, M.D. (2009) “Manic Symptoms During Depressive Episodes in 1,380 Patients With Bipolar Disorder: Findings From the STEP-BD.” Am J Psychiatry, 166:173–181)
• Altshuler L, Suppes T, Black D, Nolen WA, Keck PE Jr, Frye MA, McElroy S, Kupka R, Grunze H, Walden J, Leverich G, Denicoff K, Luckenbaugh D, Post R. (2003) “Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up.” Am J Psychiatry, 160(7): 1252-1262.

There have been numerous publications arising out of the study, too many to cover in one journal club, but you can find a nice summary at the following website: http://www.stepbd.org/referencelist.html

3/20/2009: Drugs in development for treatment of schizophrenia

Faculty discussant: Joseph Pierre, MD

• Maria J. Arranz and Shitij Kapur. (2008) “Pharmacogenetics in Psychiatry: Are We Ready for Widespread Clinical Use?” Schizophrenia Bulletin 34(6): 1130–1144.
• JA Gray and BL Roth. (2007) “The pipeline and future of drug development in schizophrenia.” Molecular Psychiatry, 12: 904–922.

4/17/2009: Neuroimaging of Social Experiences

Discussion leader: Marissa Caudill, MD PhD

• Hidehiko Takahashi, et al. (2009) "When your gain is my pain and your pain is my gain: neural correlates of envy and schadenfreude." Science 323: 937-939.

• Matthew D. Lieberman and Naomi I. Eisenberger (2009) "Pains and pleasures of social life." Science 323: 890-891.

• Simone G. Shamay-Tsoory, Yasmin Tibi-Elhanany, and Judith Aharon-Peretz (2007) "The green-eyed monster and malicious joy: the neuroanatomical bases of envy and gloating (schadenfreude)." Brain, 130:1663-1678

• Naomi I. Eisenberger, et al. (2003) "Does Rejection Hurt? An fMRI study of social exclusion." Science, 302: 290-292.

5/15/2009: Gene x Environment interactions and youth violence

Discussion leader: Marissa Caudill, MD PhD

• Steven E Hyman (2009) "How adversity gets under the skin." Nature Neuroscience, 12(3): 241-243

• Patrick O McGowan, Aya Sasaki, Ana C D’Alessio, Sergiy Dymov, Benoit Labonte, Moshe Szyf, Gustavo Turecki, & Michael J Meaney. (2009) "Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse." Nature Neuroscience, 12(3): 342-348.

6/19/2009: TBA

Faculty discussant: TBA

• readings TBA

Readings for Academic Year 2009-2010

7/24/2009: Alzheimer's disease pathogenesis and immunotherapy targets

Discussion leader: Marissa Caudill, MD PhD

• Sloop, G. D. (1999) Cellular pathogenesis of Alzheimer’s disease. Medical Hypotheses. 53(2): 127–129.

• Town, Terrence (2009) Alternative A? Immunotherapy Approaches for Alzheimer’s Disease. CNS Neurol Disord Drug Targets. 2009 April ; 8(2): 114–127.

• Wilcock, Donna M.; Gharkholonarehe, Nastaran; Van Nostrand, William E.; Davis, Judianne; Vitek, Michael P.; and Colton, Carol A. (2009) Amyloid reduction by amyloid-vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer’s disease. The Journal of Neuroscience (June 24, 2009) 29(25):7957–7965.

8/21/2009: TBA

Faculty discussant: TBA

• readings TBA

9/18/2009: Genetic risk factors for schizophrenia and bipolar disorder

Discussion leader: Michael Davis, MD PhD

• The International Schizophrenia Consortium (2009) “Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.” Nature 460(6 August 2009): 748-752.
• Mark I. McCarthy, Gonçalo R. Abecasis, Lon R. Cardon, David B. Goldstein, Julian Little, John P. A. Ioannidis, and Joel N. Hirschhorn. (2008) “Genome-wide association studies for complex traits: consensus, uncertainty and challenges.” Nature Reviews|Genetics, 9(May 2008): 356-369.
  

9/25/2009: The CATIE trial: quasi-naturalistic study of antipsychotics

Faculty discussant: Dr. Joseph Pierre

Dr. Pierre will discuss the trial, outcomes and clinical relevance. This is the largest and most current study on antipsychotics to date and is regularly cited in clinical experience and other papers. We ask that you read about the study in preparation for this lunch. Please see below for details regarding the articles. If you find yourself only able to read one, this is the recommended link:
http://archpsyc.ama-assn.org/cgi/reprint/63/10/1069

• Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. “Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.” N Engl J Med. 2005 Sep 22; 353(12): 1209-23.

http://content.nejm.org/cgi/content/abstract/353/12/1209

McEvoy JP, Lieberman JA, Stroup TS, Davis SM, Meltzer HY, Rosenheck RA, Swartz MS, Perkins DO, Keefe RS, Davis CE, Severe J, Hsiao JK; CATIE Investigators. “Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment.” Am J Psychiatry 2006; 163:600-610.

Stroup TS, Lieberman JA, McEvoy JP, Swartz MS, Davis SM, Rosenheck RA, Perkins DO, Keefe RS, Davis CE, Severe J, Hsiao JK; CATIE Investigators. “Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic.” Am J Psychiatry. 2006 Apr;163(4):611-22.

if you're only going to read one thing and not the actual studies, try looking at these brief commentaries:

http://ps.psychiatryonline.org/cgi/content/full/59/5/500

http://ps.psychiatryonline.org/cgi/content/full/59/5/523

10/16/2009: TBA

Faculty discussant: TBA

• readings TBA

10/23/2009: STAR*D, part 1: quasi-naturalistic trial of antidepressants

Faculty discussant: Dr. Ian Cook

• readings TBA

11/20/2009: TBA

Faculty discussant: TBA

• readings TBA

12/18/2009: TBA

Faculty discussant: TBA

• readings TBA

1/15/2010: TBA

Faculty discussant: TBA

• readings TBA

2/19/2010: TBA

Faculty discussant: TBA

• readings TBA

3/19/2010: TBA

Faculty discussant: TBA

• readings TBA

4/16/2010: TBA

Faculty discussant: TBA

• readings TBA

5/21/2010: TBA

Faculty discussant: TBA

• readings TBA

6/18/2010: TBA

Faculty discussant: TBA

• readings TBA

Created 2008 July 30.
Last updated 2009 Oct 9