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- Weisbroth SH. 1975. Torsion of the caudate lobe of the liver in Oryctolagus cuniculus. Vet Pathol 12:13-15.
- Wilson RB et al. 1987. Liver lobe torsion in a rabbit. Lab Anim Sci 37:506-507.
- Downs MO, Miller MA, Cross AR, Selcer BA, Abdy, M.J., Watson E. Liver lobe torsion and liver abscess in a dog. JAVMA, 212 (5), 678-680, 1998.
- Liver Lobe Torsion - From: The Biology of the Laboratory Rabbit - page 340
Liver lobe torsion has been detected (or reported) infrequently on Oryctolagus. Four of five reported cases in the US had torsion if the caudate lobe. Three of the case were detected at necropsy, apparently without accompanying clinical signs (Weisbroth SH. 1975.). The case reported by Fitzgerald and Fitzgerald (1992) presented with anorexia and weakness, was anemic and jaundiced, and had an elevated serum concentration of alanine aminotransferase. The rabbit died following 4 days of supportive therapy. Torsion of the caudate lobe, along with profuse hemothorax and pulmonary edema, was observed at postmortem examination. Older reports of caudate lobe torsion described secondary lesions ranging from abdominal transudates to frank hemorrhage and death (Rubarth, 1958).
Death was attributed to liver lobe torsion in a rabbit which had a torsion of the posterior lobule of the left hepatic lobe (Wilson, 1987). No clinical signs were detected prior to death. On necropsy, the affected lobule was enlarged and characterized microscopically by diffuse coagulative necrosis of the hepatocytes and stroma, a description identical to that of the caudate lobe torsion observed by Fitzgerald and Fitzgerald.
From Diseases And Neoplasms Of The Aging Sd Rat "Hepatotoxins which are primarily absorbed from one region of the gut may cause lesions primarily in one lobe of the liver, thus it is essential to take multiple sections of liver on toxicologic pathology studies."
*Liver torsion in horses has been associated with their diet. Note the similarities with symptoms with damage from mycotoxin poisoning (GI stasis/bloat) which sometimes preceed the liver torsion. Mycotoxins may also cause hepatocellular degeneration, fatty changes, hemorrhage and necrosis, centrolobular dystrophy of the liver, hemorrhagic hepatic dystrophy and irregular blood supply. Have your feed tested for mycotoxins at an agricultural lab near you.
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