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Reglan® (metoclopramide) and Propulsid® (cisapride) are gut motility
drugs which are given to bunnies when they have GI stasis. In some countries, Propulsid is called Prepulsid.
Reglan® stimulates movement of the *upper* GI tract through a
direct effect on dopamine receptors in the brain. It reduces nausea,
slows/soothes the stomach and intestine, and improves the absorption
of other oral medications.
Propulsid® stimulates the release of the hormone acetylcholine at key
nerve endings along the *lower* GI tract. It restores rhythmic
contractions in the intestines, so food moves out of the stomach at a
faster rate. It is more specific and targeted in its effects than
metoclopramide, with fewer side effects.
Many vets do not prescribe these drugs if there is a suspected
blockage because they believe they can rupture the stomach/intestine.
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