Maher, R.L. and Bloom, L.B. (2007) Pre-steady-state kinetic
characterization of the AP endonuclease activity of human AP endonuclease 1. J. Biol. Chem. 282, 30,577-30,585.
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Anderson, S.G., Williams, C.R., O'Donnell, M. and Bloom, L.B. (2007)
A function for the psi subunit in loading the Escherichia coli DNA polymerase sliding clamp.
J. Biol. Chem. 282, 7035-7045.
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Maher, R.L., Vallur, A.C., Feller, J.A. and Bloom, L.B. (2006) Slow base excision by human
alkyladenine DNA glycosylase limits the rate of formation of AP sites and AP endonuclease 1 does
not stimulate base excision. DNA Repair 6, 71-81.
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Hariharan, C., Bloom, L.B., Helquist, S.A., Kool, E.T., and Reha-Krantz, L.J. (2006) Dynamics
of nucleotide incorporation: Snapshots revealed by 2-aminopurine fluorescence studies.
Biochemistry 45, 2836-2844.
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Aksyonov, S.A., Bittner, M., Bloom, L.B., Reha-Krantz, L.J., Gould, I.R., Hayes, M.A., Kierman,
U.A., Niederkofler, E.E., Pizziconi, V., Rivera, R.S., Williams, D.J., and Williams, P. (2006)
Multiplexed DNA sequencing-by-synthesis. Anal. Biochem. 348, 127-138.
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Vallur, A.C., Maher, R.L. and Bloom, L.B. (2005) The efficiency of hypoxanthine excision by
alkyladenine DNA glycosylase is altered by changes in nearest neighbor bases. DNA Repair
4, 1088-1098.
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Shaw, R.W., Feller, J.A., and Bloom, L.B. (2004) Contribution of a conserved phenylalanine
residue to the activity of Escherichia coli uracil DNA glycosylase. DNA Repair 3, 1273-1283.
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Bertram, J.G., Bloom, L.B., O'Donnell, M., and Goodman, M.F. (2004) Increased dNTP binding
affinity reveals a non-processive role for Escherichia coli beta clamp with DNA polymerase IV.
J. Biol. Chem. 279, 33047-33050.
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Snyder, A.K., Williams, C.R., Johnson, A., O'Donnell, M. and Bloom, L.B. (2004) Mechanism
of loading the Escherichia coli DNA polymerase III sliding clamp. II. Uncoupling the beta and DNA binding
activities of the gamma complex. J. Biol. Chem. 279, 4386-4393.
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Williams, C.R., Snyder, A.K., Kuzmic, P., O'Donnell, M. and Bloom, L.B. (2004) Mechanism of loading
the Escherichia coli DNA polymerase III sliding clamp. I. Two distinct activities for individual ATP sites
in the gamma complex. J. Biol. Chem. 279, 4376-4385.
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Ason, B., Handayani, R., Williams, C.R., Bertram, J.G., Hingorani, M.M, O'Donnell, M., Goodman, M.F, and Bloom, L.B.
(2003) Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA:
Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp.
J. Biol. Chem. 278, 10033-10040.
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Vallur, A. C., Feller, J. A., Abner, C. W., Tran, R. K. and Bloom, L. B. (2002) Effects of hydrogen bonding within
a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase.
J. Biol. Chem. 277, 31673-31678.
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Jaiswal, A.S., Bloom, L.B., Narayan, S. (2002) Long-patch base excision repair of apurinic/apyrimidinic site DNA
is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvment of cycling-dependent kinase
inhibitor p21 Waf-1/Cip-1. Oncogene 21, 5912-5922.
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Abner, C. W., Lau, A. Y., Ellenberger, T., and Bloom, L. B. (2001) Base excision and DNA binding activities of
human alkyladenine DNA glycosylase are sensitive to the base paired with a lesion.
J. Biol. Chem. 276, 13379-13387.
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Bertram, J.G., Bloom, L.B., Hingorani, M.M., Beechem, J.M., O'Donnell, M., and Goodman, M.F. (2000) Molecular
mechanism and energetics of clamp assembly in Escherichia coli. The role of ATP hydrolysis when gamma complex loads beta onto DNA.
J. Biol. Chem. 275, 28413-28420.
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Ason, B., Bertram, J.G., Hingorani, M.M., Beechem, J.M., O'Donnell, M., Goodman, M.F., and Bloom, L.B.
(2000) A model for Escherichia coli DNA polymerase III holoenzyme assembly at primer/template ends:
DNA triggers a change in binding specificity of the gamma complex clamp loader. J. Biol. Chem. 275, 3006-3015.
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Hingorani, M.M., Bloom, L.B., Goodman, M. F., and O'Donnell, M. (1999) Division of labor - sequential ATP hydrolysis
drives assembly of a DNA polymerase sliding clamp around DNA. EMBO J 18, 5131-5144.
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Bertram, J.G., Bloom, L.B., Turner, J., O'Donnell, M., Beechem, J.M., and Goodman, M.F. (1998) Presteady-state
analysis of the assembly of wild type and mutant circular clamps of Escherichia coli DNA polymerase III on DNA.
J. Biol. Chem. 273, 24564-24574.
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Reha-Krantz, L.J., Marquez L.A., Elisseeva, E., Baker, R.P., Bloom, L.B., Dunford, H.B., and Goodman, M.F. (1998)
The proofreading pathway of bacteriophage T4 DNA polymerase. J. Biol. Chem. 273, 22969-22976.
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Otto, M.R., Bloom, L.B., Goodman, M.F., and Beechem, J.M. (1998) Stopped-flow fluorescence study of pre-catalytic
base stacking transitions in the exonuclease cleft of bacteriophage T4 DNA polymerase. Biochemistry 37, 10156-10163.
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Beechem, J.M., Otto, M.R., Bloom, L.B., Eritja, R., Reha-Krantz, L.J., and Goodman, M.F. (1998) Exonuclease/polymerase
partitioning and equilibrium Mg2+ binding properties of bacteriophage T4 DNA polymerase. Biochemistry 37,
10144-10155.
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Bloom, L.B., Chen, X., Fygenson, D.K., Turner, J., O'Donnell, M., and Goodman, M.F. (1997) Fidelity of Escherichia coli
DNA polymerase III holoenzyme: The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease
on nucleotide misincorporation efficiencies. J. Biol. Chem. 272, 27919 - 27930.
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Bloom, L. B., Turner, J., Kelman, Z., Beechem, J. M., O'Donnell, M., and Goodman, M. F. (1996) Dynamics of loading the
beta sliding clamp of DNA polymerase III onto DNA. J. Biol. Chem. 271, 30699-30708.
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Sibghat-Ullah, Galinari, P., Xu, Y.-Z., Goodman, M.F., Bloom, L.B., Jiricny, J., Day, R.S., III (1996) Base analog
and neighboring base effects on substrate specificity of recombinant human G:T mismatch-specific thymine DNA glycosylase.
Biochemistry 35, 12926-12932.
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Bloom, L. B., Otto, M. R., Eritja, R., Reha-Krantz, L. J., Beechem, J. M., and Goodman, M. F. (1994) Pre-steady-state
kinetic analysis of sequence-dependent nucleotide excision by the 3'-exonuclease activity of bacteriophage T4 DNA polymerase.
Biochemistry 33, 7576-7586.
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Bloom, L. B., Otto, M. R., Beechem, J. M., and Goodman, M. F. (1993) Influence of 5'-nearest neighbors on the insertion
kinetics of the fluorescent nucleotide analog, 2-aminopurine, by Klenow fragment. Biochemistry 32, 11247-11258.
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Cai, H., Bloom, L. B., Eritja, R., and Goodman, M. F. (1993) Kinetics of deoxyribonucleotide insertion and extension
at abasic template lesions in different sequence contexts using HIV-1 reverse transcriptase.
J. Biol. Chem. 268, 23567-23572.
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Schy, W. E., Hertel, L. W., Kroin, J. S., Bloom, L. B., Goodman, M. F., and Richardson, F. C. (1993) Effect of a
template-located 2,2'-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3' to 5' exonuclease-)
fragment. Cancer Research 53, 4582-4587.
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Yu, H., Eritja, R., Bloom, L. B., and Goodman, M. F. (1993) Ionization of bromouracil and fluorouracil stimulates
base mispairing frequencies with guanine. J. Biol. Chem. 268, 15935-15943.
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Zoltewicz, J. A., and Bloom, L. B. (1993) Paramagnetic Ni(II)-induced changes in proton T1 relaxation as an aid
in studying binding of adenine nucleosides to SDS micelles. J. Phys. Chem. 97, 2755-2758.
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Zoltewicz, J. A., Prokai-Tatrai, K., Bloom, L. B., and Kem, W. R. (1993) Long range transmission of polar effects
in cholinergic 3-arylideneanabaseines. Conformations calculated by molecular modelling. Heterocycles 35, 171-179.
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Zoltewicz, J. A., and Bloom, L. B. (1992) Evidence for two binding sites on micellization of 1-methyl-4,4'-bipyridinium
reporter ion in sodium dodecyl sulfate. J. Phys. Chem. 96, 5156-5159.
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Zoltewicz, J. A., and Bloom, L. B. (1992) Mixed micelle of cholinergic anabaseine with sodium dodecyl sulfate.
Novel determination of the binding constants. J. Phys. Chem. 96, 2007-2010.
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Zoltewicz, J. A., Bloom, L. B., and Kem, W. R. (1992) N-Methylated 2,3'-bipyridinium ion. First synthesis of
the more sterically hindered isomer. J. Org. Chem. 57, 2392-2395.
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Zoltewicz, J. A., Bloom, L. B., and Kem, W. R. (1990) Hydrolysis of cholinergic anabaseine and N-methylanabaseine:
Influence of cosolvents on the position of the ring-chain equilibrium - compensatory changes. Bioorganic Chem. 18, 395-412.
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Zoltewicz, J. A., and Bloom, L. B. (1990) The apparent pKa of the oxidation product of spermine or spermidine: a pKa masked by a
ring-chain tautomeric equilibrium. Bioorganic Chem. 18, 85-90.
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Zoltewicz, J. A., Bloom, L. B., and Kem, W. R. (1989) Quantitative determination of the ring-chain hydrolysis equilibrium
constant for anabaseine and related tobacco alkaloids. J. Org. Chem. 54, 4462-4468.
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