Perhaps one of the most popular podcasts around, Rocketboom has a significant following. I have been watching this newscast on a daily basis for the better part of a year. CSI fans will recognize the format - if not the hostess - from an episode last season. The reports are interesting and timely, and the current hostess is almost as good as Amanda Congdon (the former hostess).
Forbidden Cocktails in a Swank Pad. Certainly one of my favorites, this popular podcast has been referenced a number of times both in popular media and by Steve Jobs. Unfortunately, the episodes are not released as regularly as a podcast such as Rocketboom, but everyone is entertaining nonetheless. They have regular guest stars that really shake things up - and yes, that Martian is from Battlestar Galactica.