A Canticle for Leibowitz by Walter M. Miller, Jr.
Dune by Frank Herbert
Do Androids Dream of Electric Sheep? by Philip K. Dick
Araminta Station by Jack Vance
Ecce and Old Earth by Jack Vance
Throy by Jack Vance
The Demon Princes, Vol. I by Jack Vance
The Demon Princes, Vol. II by Jack Vance
Tales of the Dying Earth by Jack Vance
The Stars My Destination by Alfred Bester
The Demolished Man by Alfred Bester
The Man in the High Castle by Philip K. Dick
The Last Coin by James P. Blaylock
The Rainy Season by James P. Blaylock
The Paper Grail by James P. Blaylock
Night Relics by James P. Blaylock
All the Bells on Earth by James P. Blaylock
Land of Dreams by James P. Blaylock
The Anubis Gates by Tim Powers
The Drawing of the Dark by Tim Powers
On Stranger Tides by Tim Powers
Dinner at Deviant's Palace by Tim Powers
A Deepness in the Sky by Vernor Vinge
A Fire Upon the Deep by Vernor Vinge [I've only read these two Vinge novels twice, but they still rank. So-called "space operas" take a long time to read!]
Marooned in Realtime by Vernor Vinge
Shadow & Claw by Gene Wolfe
Sword & Citadel by Gene Wolfe
Urth of the New Sun by Gene Wolfe
Litany of the Long Sun by Gene Wolfe
Epiphany of the Long Sun by Gene Wolfe
On Blue's Waters by Gene Wolfe
In Green's Jungle by Gene Wolfe
Return to the Whorl by Gene Wolfe
The Fifth Head of Cerberus by Gene Wolfe
Peace by Gene Wolfe
There are Doors by Gene Wolfe
Ender's Game by Orson Scott Card
Speaker for the Dead by Orson Scott Card
Xenocide by Orson Scott Card
Nostrilia by Cordwainer Smith
The Rediscovery of Man by Cordwainer Smith
Neuromancer by William Gibson
The Golden Age by John C. Wright
Something Wicked This Way Comes by Ray Bradbury