| Jake Kushner Lab A Research Group Focused on Beta-Cell Regeneration Division of Endocrinology and
Diabetes,
Children's Hosptital of Philadelphia, Institute for Diabetes Obesity
and Metabolism, Institute for Regenerative Medicine, University of
Pennsylvania School
of Medicine
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| Mission
Statement |
Overview |
| Beta Cell Progenitors | Beta Cell Turnover |
| Cell Cycle Regulation of Beta Cells | Conclusions |
| Publications | The P.I. |
| Group Members | Contact Us |
| Directions | Parent
Organizations |
| Organizations
We Support |
|




He
LM, Sartori DJ, Teta M, Opare-Addo, LM, Rankin MM, Long SY, Diehl JA,
Kushner JA: Cyclin D2 Protein Stability Is Regulated In Pancreatic Beta
Cells. Molecular Endocrinology 2009 Notes: Article In Press.
Link
Granger Anne, Kushner Jake A.: Cellular Origins of Beta Cell
Regeneration: a Legacy View of Historical Controversies. Journal of
Internal Medicine 266(4): 325-38, October 2009. Link
Rankin MM, Kushner JA: Adaptive beta-cell proliferation is severely
restricted with advanced age. Diabetes 58(6): 1362-72, Mar 2009. Link
Kiel Mark J, He Shenghui, Ashkenazi Rina, Gentry Sara N, Teta Monica,
Kushner Jake A, Jackson Trachette L, Morrison Sean J: Haematopoietic
stem cells do not asymmetrically segregate chromosomes or retain BrdU.
Nature 449(7159): 238-42, Sep 2007. Link
Teta Monica, Rankin Matthew M, Long Simon Y, Stein Geneva M, Kushner
Jake A: Growth and regeneration of adult beta cells does not involve
specialized progenitors. Developmental cell 12(5): 817-26, May 2007. Link
Teta Monica, Long Simon Y, Wartschow Lynn M, Rankin Matthew M, Kushner
Jake A: Very slow turnover of beta-cells in aged adult mice. Diabetes
54(9): 2557-67, Sep 2005. Link
Kushner Jake A: Beta-cell growth: an unusual paradigm of organogenesis
that is cyclin D2/Cdk4 dependent. Cell cycle 5(3): 234-7, Feb 2006. Link
Kushner Jake A, Ciemerych Maria A, Sicinska Ewa, Wartschow Lynn M, Teta
Monica, Long Simon Y, Sicinski Piotr, White Morris F: Cyclins D2 and D1
are essential for postnatal pancreatic beta-cell growth. Molecular and
cellular biology 25(9): 3752-62, May 2005. Link
| Jake
Kushner |
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Education: 1987 B.A. University of California at Berkeley (Biochemistry) 1994 M.D. Albany Medical College Postgraduate Training and Fellowship Appointments: 1994-1997 Pediatrics Resident, Rhode Island Hospital, Brown University 1997-2000 Clinical Fellow in Pediatric Endocrinology, Children's Hospital, Boston 1998-1999 Postdoctoral Research Fellow, Laboratory of Marc Montminy, Joslin Diabetes Center, Department of Cell Biology, Harvard Medical School 1999-2003 Postdoctoral Research Fellow, Laboratory of Morris White, Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School Faculty Appointments: 2000-2003 Instructor in Medicine, Department of Pediatrics, Harvard Medical School 2004-present Assistant Professor of Pediatrics, University of Pennsylvania School of Medicine 2004-present Faculty, Cell and Molecular Biology Graduate Group, Developmental, Stem Cell and Regenerative Biology Program Awards and Honors: 1999-2000 Lawson Wilkins Pediatric Endocrinology Society, Eli Lilly Fellowship 2001-2003 Juvenile Diabetes Research Foundation International Postdoctoral Research Fellowship 2003-2005 Charles H. Hood Foundation Child Health Research Grant 2003-2005 Lawson Wilkins Pediatric Endocrinology Society Clinical Scholar Award 2003-2008 NIH Mentored Clinical Scientist Career Development Award 2003-2009 NIH Pediatric Research Loan Repayment Program (competitive renewal x 2) 2009 Member, American Society of Clinical Investigation UPENN Graduate School Teaching: 2005 CAMB 605. Faculty member of first year seminar series in the Cellular And Molecular Biology Graduate Program. 2007 CAMB 632, Course Co-Director. Cell Control by Signal Transduction Pathways. 2008 CAMB 632, Course Co-Director. Cell Control by Signal Transduction Pathways. 2009 CAMB 530, Course Co-Director. The Cell Cycle and Cancer. |
| Matthew Rankin, BA | Kim Rak, BA |
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| Research Technician | Research Technician |
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Alex Tuttle, BA |
Dan Sartori, BA |
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| Research Technician |
Research Technician |
| Anne
Granger PhD |
Alisa
Schiffman DO |
| Postdoctoral Research Fellow | Pediatric Endocrinology Fellow |
| Di Zhou | Gina Kim |
| Undergraduate Research Fellow (U Penn) | Undergraduate Research Fellow (U Penn) |
| Shirley
Ahn |
Carol
Lam |
| Undergraduate Research Fellow (U Penn) | Undergraduate Research Fellow (U Penn) |
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The Children's
Hospital of Philadelphia
The Joseph Stokes Jr. Research Institute · Leonard and Madlyn Abramson Pediatric Research Center 3615 Civic Center Blvd. Philadelphia, PA 19104 |
Click
on this link for a map of the Abramson Building (Stokes Institute) at
CHOP NOTE: Our
building is at the intersection of Osler Circle and Civic
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with security and take the elevators to the 8th
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Office: ARC 802c Lab: ARC 804 |
| Children's
Hospital
of Philadelphia Division of Endocrinology, ARC 802c 3615 Civic Center Blvd. Philadelphia, PA 19104 USA email: last name immediately followed by first initial (and all one word) at mail dot med dot upenn dot edu example for a fictional person whose first name is "First" and last name is "Last": lastf@mail.med.upenn.edu Tel : 1 267 426 5717 Fax: 1 215 590 1605 Lab Tel: 215-590-4572 |