火 - 10月 5, 2004

The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner


Satoshi Takabuchi, Kiichi Hirota, Kenichiro Nishi, Seiko Oda, Tomoyuki Oda, Koh Shingu, Arimichi Takabayashi, Takehiko Adachi, Gregg L. Semenza, and Kazuhiko Fukuda

Posted at 07:12 午後     Read More    

土 - 9月 11, 2004

The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide- soluble guanylyl cyclase pathway


Satoshi Takabuchi, Kiichi Hirota, Kenichiro Nishi a, Seiko Oda, Tomoyuki Oda, Koh Shingu, Arimichi Takabayashi, Takehiko Adachi, Gregg L. Semenza and Kazuhiko Fukuda

Biochemical and Biophysical Research Communications, vol. 324 p417-23

Posted at 12:46 午後     Read More    

月 - 8月 16, 2004

The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1


Kenichiro Nishi, Kiichi Hirota, Satoshi Takabuchi, Seiko Oda, Kazuhiko Fukuda, Takehiko Adachi, and Koh Shingu

Journal of Anesthesia, In press

Posted at 03:40 午後     Read More    

Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin


Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin.

Guo Y, Einhorn L, Kelley M, Hirota K, Yodoi J, Reinbold R, Scholer H, Ramsey H, Hromas R.
Stem Cells. 2004;22(3):259-64.

Posted at 03:37 午後     Read More    

月 - 8月 9, 2004

Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy


Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy

Kiichi Hirota, Tomoko Hara, Satoshi Hosoi, Yukiko Sasaki, Yasufumi Hara and Takehiko Adachi

Jounal of Anesthesia, In press

Posted at 03:13 午後     Read More    

金 - 7月 30, 2004

The Volatile anesthetics halothane and isoflurane differentially modulate pro-inflammatory cytokines-induced p38 mitogen-activated protein kinase activation


Itoh, T., Hirota, K., Hisano, T., Namba, T. and Fukuda, K.
J. Anesth, vol.18, pp203-209
DOI: 10.1007/s00540-004-0237-5

Posted at 08:17 午後     Read More    

金 - 7月 23, 2004

Induction of Hypoxia-Inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling


Kiichi Hirota, Ryo Fukuda, Satoshi Takabuchi, Shinae Kizaka-Kondoh, Takehiko Adachi, Kazuhiko Fukuda, and Gregg L. Semenza

Posted at 08:13 午前     Read More    

土 - 2月 21, 2004

Cell Type-Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1


Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL.

Posted at 12:40 午後     Read More    

日 - 11月 9, 2003

Molecular mechanisms of transcription activation by HLF and HIF1alpha in
response to hypoxia: their stabilization and redox signal-induced interaction
with CBP/p300. EMBO J


Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L., and Fujii-Kuriyama, Y. (1999)

Posted at 05:22 午後     Read More    

Identification of thioredoxin binding protein-2/vitamin D3 up-regulated
protein 1 as a negative regulator of thioredoxin function and expression. J.
Biol. Chem


Nishiyama, A., Iwata, S., Matsui, M., Hirota, K., Masutani, H., Nakamura, H., Takagi, Y., Sono, H., Gon, Y., and Yodoi, J. (1999).

Posted at 05:21 午後     Read More    

Mouse glutaredoxin- cDNA cloning, high level expression in E. coli and its
possible implication in redox regulation of the DNA binding activity in
transcription factor PEBP2


Nakamura, T., Ohno, T., Hirota, K., Nishiyama, A., Nakamura, H., Wada, H., and Yodoi, J. (1999).

Posted at 05:20 午後     Read More    

Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function. J. Biol. Chem


Makino, Y., Yoshikawa, N., Okamoto, K., Hirota, K., Yodoi, J., Makino, I., and Tanaka, H. (1998).

Posted at 05:19 午後     Read More    

Thioredoxin target molecules in redox signal cascade. Pathophysiology


Yodoi, J., Nishiyama, A., Oono, T., Hirota, K., and Masutani, H. (1998).

Posted at 05:18 午後     Read More    

Redox regulation of glucocorticoid receptor. Pathophysiology


Tanaka, H., Makino, Y., Okamoto, K., Hirota, K., Yodoi, J., Ogawa, H., Umesono, K., and Makino, I. (1998).

Posted at 05:17 午後     Read More    

Differential expression of glutaredoxin and thioredoxin during monocytic
differentiation. Immunol. Lett


Takashima, Y., Hirota, K., Nakamura, H., Nakamura, T., Akiyama, K., Chen, F.-S., Maeda, M., and Yodoi, J. (1999).

Posted at 05:16 午後     Read More    

Thioredoxin-dependent redox regulation of p53-mediated p21 activation. J.
Biol. Chem

Demonstration of the interaction of thioredoxin with p40phox, a phagocyte
oxidase component using yeast two-hybrid system. Immunol. Lette

Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha. Biochem Biophys Res Commun.

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus: A Two Step Mechanism of Redox Regulation of Transcription Factor NF-kB. J. Biol.
Chem

Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide
scavenger, on production of nitric oxide in RAW 264.7 macropahages. Biochim.
Biophys. Acta

Thioredoxin Inhibits Tumor Necrosis Factor- or Interleukin-1-induced NF-kB
activation at the level upstream of NF-kB-inducing kinase. Antiox. Redox
Signal

Nucleoredoxin, Glutaredoxin, and Thioredoxin differentially regulate NF-kB,
AP-1, and CREB activation in HEK293 cells. Biochem. Biophys. Res. Commun

Geranylgeranylacetone enhances expression of thioredoxin and suppresses
ethanol-induced cytotoxicity in cultured hepatocytes. Biochem. Biophys. Res.
Commun

Thioredoxin nuclear translocation and interaction with redox factor-1
activates the AP-1 transcription factor in response to ionizing radiation.
Cancer Res

Geranylgeranylacetone promotes induction and secretion of thioredoxin in
gastric mucosal cells and periferal blood lymphocytes. Free Rad. Res

6-Formylpterin, a xanthine oxidase inhibitor, intracellulary generates reactive oxigen species involved in apoptosis and cell proliferation. Free
Redical Biol. Med.

An endogenous redox molecules, thioredoxin regulates signalling pathway of
the NF-kB activation by lysophosphatidic acid. FEBS Lett

Redox-sensitive transactivation of epidermal growth factor receptor by
tumor necrosis factor confers the NF-kB activation. J Biol Chem

Reversible inhibition of hypoxia-inducible factor 1 activation by exposure
of hypoxic cells to the volatile anesthetic halothane. FEBS Lett

Small GTPase protein Rac1 plays an essential role in hypoxia-inducible factor 1 activation in hypoxia. J Biol Chem

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