1.- Soto-Otero,
R.,
Méndez-Alvarez, E., Sierra-Paredes, G., Galán-Valiente,
J., Aguilar-Veiga, E. and Sierra-Marcuño, G. HPLC Procedure for
Quantitative
Determination of Pentylenetetrazol in Serum and Discrete Areas of the
Rat Brain.
Analytical Biochemistry, 165: 331-336, 1987.
2.- Soto-Otero, R., Méndez-Alvarez, E., Sierra-Paredes, G.,
Galán-Valiente,
J., Aguilar-Veiga, E. and Sierra-Marcuño, G. A Rapid Method for
the Determination
of Benzilpenicillin in Serum by RP-HPLC. Biomedical Chromatography, 2:
177-179, 1987.
3.- Soto-Otero, R., Méndez-Alvarez, E., Sierra-Paredes, G.,
Galán-Valiente,
J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Simultaneous
determination of
the two components of picrotoxin in serum by reversed phase
chromatography and its
application to pharmacokinetics studies in rats. J. Pharmac. Biomed
Anal., 7: 369-375,
1989.
4.- Sierra-Paredes, G., Soto-Otero, R., Mendez-Alvarez, E.,
Galán-Valiente,
J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Experimental spike
and wave discharges
induced by pentylenetetrazol and tolerance to repeated injections: an
electrophysiological
and biochemical study. Epilepsy Research, 4: 139-146, 1989.
5.-
Sierra-Paredes, G.,
Soto-Otero, R., Mendez-Alvarez, E., Galán-Valiente, J.,
Aguilar-Veiga, E.
and Sierra-Marcuño, G. A Quantifiable Nonconvulsive Model of
Experimental
Epilepsy: An Electrophysiological and Biochemical Study. Epilepsia, 29:
667, 1989
6.- Méndez-Alvarez, E., Soto-Otero, R., Sierra-Paredes, G.,
Aguilar-Veiga,
E., Galán-Valiente, J. and Sierra-Marcuño, G. Effects of
carbamazepine
on the pharmacokinetics and brain levels of phenobarbital after acute
and chronic
administration in the rat. 2nd International Symposium on
Pharmaceutical and Biomedical
Analyisis. 1990.
7.-Aguilar-Veiga,
E., Sierra-Paredes,
G., Galán-Valiente, J., Soto-Otero, R., Méndez-Alvarez,
E. y Sierra-Marcuño,
G. Possible role of blood-brain barrier in the time course of
ethosuximide in the
brain. Epilepsia, 31, 5: 602, 1990.
8.-
Méndez-Alvarez, E., Soto-Otero, R., Sierra-Paredes, G.,
Aguilar-Veiga,
E., Galán-Valiente, J. and Sierra-Marcuño, G.
Reversed-phase Liquid
Chromatography Method for the Simultaneous Determination of Several
Common Penicillins
in Human Serum. Biomedical Chromatography, 5: 78-82, 1991.
9.- Soto-Otero, R.,
Méndez-Alvarez, E., Sierra-Paredes, G.,
Galán-Valiente,
J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Reversed-phase HPLC
method for
the determination of bemegride in serum and brain tissue:
pharmacokinetics and brain
distribution of an intraperitoneal subconvulsive dose in rats. J.
Pharmac. Biomed.
Anal., 9, 2: 177-182, 1991.
10.- Aguilar-Veiga, E., Sierra-Paredes, G., Galán-Valiente, J.,
Soto-Otero,
R., Méndez-Alvarez, E. and Sierra-Marcuño, G. Correlation
between ethosuximide
brain levels measured by high performance liquid chromatography and its
antiepileptic
potential. Research Communications in Chemical Pathology and
Pharmacology, 71, 3:
351-364, 1991.
11.-
Soto-Otero, R., Méndez-Alvarez,
E., Galán-Valiente, J., Aguilar-Veiga, E. and
Sierra-Marcuño, G. Quantitative
analysis of neuroactive amino acids in brain tissue by liquid
chromatography using
fluorescent pre-column labelling with o-phthalaldehide and
N-acetyl-L-cysteine. Biomedical
Chromatography, 8:114-118, 1994.
12.-
Sierra-Paredes, G.
and Sierra-Marcuño, G. Effects of local perfusion of NMDA
antagonists on seizures
induced by picrotoxin in the rat hippocampus. Epilepsia, 34, supplement
4: 42, 1995.
13.-G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes,
E. Aguilar-Veiga,
R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño.
Transmitter
amino acid levels in seizures induced by picrotoxin microperfusion in
the hippocampus
of freely moving rats. Epilepsia 37, suppl. 4: 135, 1996.
14.-G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes,
E. Aguilar-Veiga,
R. Soto-Otero, E. Méndez-Alvarez and G.
Sierra-Marcuño.Role of transmitter
amino acid levels and NMDA receptors on the thresholds of
picrotoxin-induced seizures
n the hippocampus . Epilepsia 37, suppl 5: 40, 1996
15.- Sierra-Paredes, G. and Sierra-Marcuño, G. Microperfusion of
picrotoxin
in the hippocampus of chronic freely moving rats through microdialysis
probes: A
new method of induce partial and secondary generalizad seizures.
Journal of Neuroscience
Methods. 67: 113-120, 1996.
16.- Sierra-Paredes, G. and Sierra-Marcuño, G. Effects of NMDA
antagonists
on seizure thresholds induced by intrahippocampal microdialysis of
picrotoxin in
freely moving rats. Neuroscience Letters, 218: 62-66, 1996.
17.-G.
Sierra-Paredes,
J. Galán-Valiente, M.D. Vazquez-Illanes, E. Aguilar-Veiga, R.
Soto-Otero,
E. Méndez-Alvarez and G. Sierra-Marcuño. Effects of
Dizocilpine and
Diazepam on hippocampal amino acid levels during picrotoxin-induced
seizures. Epilepsia,
38, suppl. 6, 1997
18.- G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes,
E. Aguilar-Veiga,
R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño.
Effects of
AMPA and NMDA receptor antagonists on seizure thresholds and
extracellular amino
acids in seizures induced by intrahippocampal picrotoxin
microperfusion. Epilepsia,
38, suppl 7, 1997
19.- Sierra-Paredes, G., Galán-Valiente, J., Vazquez-Illanes,
M.D., Aguilar-Veiga,
E., Soto-Otero, R., Méndez-Alvarez, E. and
Sierra-Marcuño, G. Extracellular
amino acids in the rat hippocampus during picrotoxin threshold seizures
in chronic
miceodialysis experiments. Neuroscience Letters, 248: 53-56, 1998.
20.- G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes,
E. Aguilar-Veiga,
R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño.
Effects of
non-NMDA receptor antagonists on extracellular amino acids
concentrations in seizures
induced by intrahippocampal picrotoxin microperfusion. Epilepsia, 39,
suppl 6: 13,
1998
21.- G. Sierra-Paredes, A. Senra-Vidal and G. Sierra-Marcuño.
Effects of glutamate
and glycine intrahippocampal microperfusion on the picrotoxin seizure
threshold in
freely moving rats. Epilepsia, 40, suppl 7: 5, 1999.
22.-
Sierra-Paredes, G, Cornes, J.M. and
Sierra-Marcuño, G.Calpain inhibitor
I reatrds seizure arrest in the hippocampus of freely moving rats.
Neuroscience Letters,
263:165-168, 1999.
23.- Sierra-Paredes,
G., Galán-Valiente, J.,.Vazquez-Illanes, M. D., Aguilar-Veiga,
E. and Sierra-Marcuño,
G. . Effect of ionotropic glutamate receptors antagonists on the
modifications in extracellular glutamate and aspartate levels during
picrotoxin seizures: a microdialysis study in freely moving rats.
Neurochemistry
International,
37 (4): 377-386, 2000
24.-
G.
Sierra-Paredes
and G. Sierra-Marcuño. In vivo microdialysis: A two way road in
the search
for new pharmacological targets. 2nd International Symposium on
Microdialysis in
Drug Research and Development, Stockholm, Sweden, June 14-17, 2000.
25.- G. Sierra-Paredes, M.T. Oreiro-García, J.M. Cornes and G.
Sierra-Marcuño.
Long-term decrease in picrotoxin seizure threshold induced by in vivo
actin depolymerization
in the rat hippocampus. Epilepsia, 41, suppl 7: 23, 2000.
26.-
Sierra-Paredes,
G., Senra-Vidal, A. and Sierra-Marcuño, G. Effect of
extracellular long-time
microperfusion of high concentrations of glutamate and glycine on
picrotoxin seizure
thresholds in the hippocampus of freely moving rats. Brain Research,
888: 19-25.
2001.
27.- G.
Sierra-Paredes,
M.T. Oreiro-García,
A. Núñez-Rodríguez and G. Sierra-Marcuño.
Induced actin
disruption: A new experimental model of epilepsy. Epilepsia, 42 (s7),
2001.
28.- G. Sierra-Paredes, A. Vázquez-López, M.T.
Oreiro-García,
A. Núñez-Rodríguez and G. Sierra-Marcuño.
Seizures induced
by perfusing glutamate and glycine in rats pretreated with latrunculin
A. Epilepsia,
43, 2002.
29.-
Sierra-Paredes, G. and Fuster, JM. Reversible impairment of an
auditory-visual association
task during cooling of prefrontal cortex. In S. Lomber, R. Galuske
(eds), Virtual
lesions. Examining cortical function with reversible deactivation.
Oxford University
Press, Oxford 2002.
30.- G. Sierra-Paredes, M.T. Oreiro-García, A.
Vázquez-López,
A. Núñez-Rodríguez and G. Sierra-Marcuño.
Effect of novel
anticonvulsant Bia 2-093 on seizures induced by picrotoxin
microdialysis in the rat
hippocampus. Epilepsia, 45, 2004.
31.-
Araceli
Vázquez-López, Germán Sierra-Paredes and
Germán Sierra-Marcuño. Role of cAMP-dependent protein
kinase on acute picrotoxininduced seizures. Neurochem. Res. 30 (5):
613-618, 2005 .
32.-Araceli
Vázquez-López, Germán Sierra-Paredes and
Germán Sierra-Marcuño. Seizures induced by microperfusion
of glutamate and glycine in the hippocampus of rats pretreated with
latrunculin A. Neuroscience Letters 388: 81-85, 2005.
33.- M.
Teresa Oreiro-García, M.
Dolores
Vázquez-Illanes, Germán Sierra-Paredes and Germán
Sierra-Marcuño. Analysis of neuroactive amino acids from
microdialysate samples by fluorescence detection using a modification
of the
6-aminoquinolyl-N-hydroxysuccinimidyl carbamate method. Biomed. Chrom.
19, 720-724, 2005.
34.- G. Sierra-Paredes, M.T.
Oreiro-García, A. Vázquez-López,
A. Núñez-Rodríguez and G. Sierra-Marcuño.
Neurochemistry of Epileptic Seizures: The role of f-Actin,
Intercellular Glutamate, and Glutamate Ionotropic Receptors
Location. In:
Robert
Coleman (Ed), Focus
on Neurochemistry Research, Nova Science Publishers, NY, USA, 2005 pp:
157-195.
35. G.
Sierra-Paredes, A. Vázquez-López, and G.
Sierra-Marcuño. Anticonvulsant effect of PKA and calcineurin
inhibitors against seizures induced by picrotoxin microdialysis in the
rat hippocampus. Epilepsia 46 (8), 10, 2005.
36. G. Sierra-Marcuño, M.T. Oreiro-García, M.D
Vázquez-Illanes, and G. Sierra-Paredes. Effect of novel
anticonvulsant BIA 2-093 on latrunculin A-induced seizures and
extracellular glutamate concentrations in the rat hippocampus.
Epilepsia 46 (8), 302, 2005.
37.-Sierra-Paredes,
G.,
Oreiro-García, M.T.,
Núñez-Rodríguez, A.
Vázquez-López, A. and Sierra-Marcuño, G.
Seizures induced by in vivo latrunculin A and jasplakinolide
microperfusion in the rat hippocampus. Journal of Molecular
Neuroscience, 28 (2), 151-160, 2006
38.
Vázquez-López A, Sierra-Paredes G, Sierra-Marcuño
G. Anticonvulsant effect of the calcineurin inhibitor ascomycin on
seizures induced by picrotoxin microperfusion in the rat
hippocampus.Pharmacol Biochem Behav. 2006 Jul;84(3):511-6.
39.
Sierra-Paredes G,
Núñez-Rodriguez A, Vázquez-López A,
Oreiro-García T, Sierra-Marcuño G.
Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on
seizures induced by microperfusion of picrotoxin in the hippocampus of
freely moving rats. Epilepsy Res. 2006 Dec;72(2-3):140-6.
40.
Oreiro-García MT, Vázquez-Illanes MD, Sierra-Paredes G,
Sierra-Marcuño G. Changes in extracellular amino acid
concentrations in the rat hippocampus after in vivo actin
depolymerization with latrunculin A. Neurochem Int. 2007
Apr;50(5):734-40.
41.
G. Sierra-Paredes, M. Oreiro-García, M. Vázquez-Illanes,
G. Sierra-Marcuño Effect of eslicarbazepine acetate (BIA 2-093)
on latrunculin A-induced seizures and extracellular amino acid
concentrations in the rat hippocampus. Epilepsy Research, Volume 77,
Issue 1, Pages 36-43, 2007
42. Sierra-Paredes G, Sierra-Marcuño G. Extrasynaptic GABA and
glutamate receptors in epilepsy. CNS Neurol Disord Drug Targets. 2007
Aug;6(4):288-300.
43.
Sierra-Paredes G, Sierra-Marcuño G. Ascomycin and FK506:
Pharmacology and Therapeutic Potential as Anticonvulsants and
Neuroprotectants. CNS Neuroscience & Therapeutics 14 (1) , 36–46,
2008.
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