Interpretation of results is final and crucial step of quantitative analysis. We summarized the information necessary to properly interpret the results of calculations in a table*:
Coefficient
Standard values
Values indicating colocalization
Values indicating absence of colocalization
Pearson's correlation coefficient (Rr)
From -1.0 to 1.0
From 0.5 to 1.0
From -1.0 to 0.5
Manders' overlap coefficient (R)
From 0 to 1.0
From 0.6 to 1.0
From 0 to 0.6
Overlap coefficients k1 and k2
Vary
Close values (0.5 and 0.6, 0.8 and 0.9)
Distant values (0.5 and 0.9, 0.2 and 0.7)
Colocalization coefficients m1 and m2
Above 0.5
Below 0.5
Colocalization coefficients M1 and M2
*Complete quantitative colocalization analysis protocol can be found in Current Protocols in Cell Biology.
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