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semester 1  
  Notes::

 

 
 

Total Body Radiation TBI

 

Data on TBI is gathered from radiation accidents (Chernobyl, 3 Mile Island, Los Alamos) and from animal models.

 

We are constantly being irradiated :

 

External :

  • Terrestial radiation (RADON) / .05 rem per year
  • Cosmic radiation / .05 rem per year

 

Internal :

  • Carbon 14
  • Radon in lungs
  • Radioactive potassium
  • .025 rem per year

 

Medical exposure :

  • xrays, floroscopy

 

 

In the U.S. we get from .075 to 5 rem per year / average = .125 rem per year

 

What happens when people get a high one shot TBI :

Radiation sickness

Symptoms :

  • headache
  • dizziness
  • malaise
  • abnormal taste and smell
  • NVD
  • Decrease in BP and WBC’s and platelets
  • Insomnia

 

 

Among the people irradiated survival or death depends on the dose received :

3 – 5 Gy – 50% of this group will die because of bone marrow damage within 2 months

 

10 – 50 Gy – no survivors.   They die from GI damage in 1 –2   weeks

 

100 Gy – no survivors.   Die from CNS damage in hours to days.

 

 

Among the survivors they will either display Somatic Effects and Genetic Effects.

 

Somatic Effects (happens to the persons own body) :

Early effects : NVD syndrome, fever,chills, fatigue, hemmoraghing, ulcers, blood count suppression, they are extremely prone to infection

 

Late effects :

•  Radiologic aging – they look older than stated age

•  Radiation carcinogenesis – develop leukemia, thyroid cancer, bone cancers, lung cancers

•  Permanent sterility

•  Bone deformities

•  Cataracts

•  Overall life shortening

 

Who survives depends on age

Young children moght have slow bone development and boys might become sterile