Lidocaine
Lidocaine NMR Samples
Friday--Feb 15, 2008 Filed in: 333
The latest spectra are
now posted online. The lidocaine specs look
pretty good!! The final product, lidocaine
bisulfate, is not very soluble in CDCl3, which is why
some of you may have observed cloudy NMR sample
solutions. The book uses dimethyl sulfoxide
(DMSO) for the NMR sample, which is much more polar
and better able to dissolve your final product.
We don't have any DMSO currently, so CDCl3 will
have to do; Navid's spectra turned out great in CDCl3
anyway. Just be aware that the chemical shift
values (ppm) for each proton signal will be slightly
different than those reported in your textbook since
chemical shift is solvent dependent.
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