AAC(6')

The AAC(6') aminoglycoside acetyltransferases inactivate aminoglycoside antibiotics such as kanamycin, tobramycin, amikacin and gentamycin by acetylating their substrates at the 6' position. Based on size and functional similarity the AAC(6') enzymes were considered to all be memebers of a single family. Phylogenetic analysis shows that instead they fall into three distinct classes, [A], [B] and[C]. Members of the same class exhibit sequence homology, but members of different classes exhibit no detectable sequence homology. Acetylation of aminoglycosides at the 6' position has evolved independently at least three times.

The three phylogenies are shown. All are described in the same paper, and all three are included in the downloadable phylogeny and key with accession numbers.

Download the phylogenies with a key that includes accession numbers.

Download the paper in which the phylogenies were published.